This bug was fixed in Patch 1.94.147
If I want to edit a werewolf in CAS paint mode after placing them in the world, none of the changes are saved and they are all gone when going back to Live Mode
It’s like the game doesn’t save any changes if a werewolf is taken to CAS with either Change Sim or the cheat Modify in CAS. This only happens if you are in werewolf form when you go to CAS though.
Before clicking on the mirror/dresser/Sim to take your werewolf to CAS, make sure they are in Human form. This should retain the changes.